InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALB

Summary

InnateDB Protein

IDBP-23586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALB

Protein Name

albumin

Synonyms

ANALBA; FDAH; PRO0883; PRO0903; PRO1341;

Species

Homo sapiens

Ensembl Protein

ENSP00000295897

InnateDB Gene

IDBG-23584 (ALB)

Protein Structure

UniProt Annotation

Function

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. {ECO:0000269PubMed:19021548}.

Subcellular Localization

Secreted.

Disease Associations

Dysalbuminemic hyperthyroxinemia (DH) [MIM:103600]: A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity. {ECO:0000269PubMed:7852505, ECO:0000269PubMed:8048949, ECO:0000269PubMed:9329347, ECO:0000269PubMed:9589637}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	173 [view]
Protein-Protein	165 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005504	fatty acid binding
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0015643	toxic substance binding
GO:0016209	antioxidant activity
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0030170	pyridoxal phosphate binding
GO:0051087	chaperone binding

Biological Process

GO:0001895	retina homeostasis
GO:0002576	platelet degranulation
GO:0006810	transport
GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0008206	bile acid metabolic process
GO:0009267	cellular response to starvation
GO:0010033	response to organic substance
GO:0015721	bile acid and bile salt transport
GO:0019836	hemolysis by symbiont of host erythrocytes
GO:0030168	platelet activation
GO:0042157	lipoprotein metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043069	negative regulation of programmed cell death
GO:0043252	sodium-independent organic anion transport
GO:0044281	small molecule metabolic process
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046689	response to mercury ion
GO:0051659	maintenance of mitochondrion location
GO:0055085	transmembrane transport
GO:0070541	response to platinum ion

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031093	platelet alpha granule lumen
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle