Version 5.4
Homo sapiens Protein: CCDC101
Summary
InnateDB Protein IDBP-22877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC101
Protein Name coiled-coil domain containing 101
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000316114
InnateDB Gene IDBG-22875 (CCDC101)
Protein Structure
UniProt Annotation
Function Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation. {ECO:0000269PubMed:19103755}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035064 methylated histone binding
Biological Process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043966 histone H3 acetylation
GO:0071169 establishment of protein localization to chromatin
Cellular Component
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0070461 SAGA-type complex
Protein Structure and Domains
PDB ID
InterPro IPR010750 SGF29 tudor-like domain
PFAM PF07039
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96ES7
PhosphoSite PhosphoSite-Q96ES7
TrEMBL
UniProt Splice Variant
Entrez Gene 112869
UniGene Hs.655476
RefSeq NP_612423
HUGO HGNC:25156
OMIM 613374
CCDS CCDS10635
HPRD 13996
IMGT
EMBL AK057008 BC011981
GenPept AAH11981 BAB71340

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca