Version 5.4
Homo sapiens Protein: CINP
Summary
InnateDB Protein IDBP-21109.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CINP
Protein Name cyclin-dependent kinase 2 interacting protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000216756
InnateDB Gene IDBG-21107 (CINP)
Protein Structure
UniProt Annotation
Function Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. {ECO:0000269PubMed:16082200, ECO:0000269PubMed:19889979}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19889979}. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0007049 cell cycle
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR023250 Cyclin-dependent kinase 2-interacting protein
PFAM
PRINTS PR02040
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BW66
PhosphoSite PhosphoSite-Q9BW66
TrEMBL A0A024R6M9
UniProt Splice Variant
Entrez Gene 51550
UniGene Hs.736782
RefSeq NP_116019
HUGO HGNC:23789
OMIM 613362
CCDS CCDS9972
HPRD 16715
IMGT
EMBL AF228148 AF228149 AK056112 AL137229 BC000600 BU174070 CH471061 CR457178 DA167716
GenPept AAF44747 AAF44748 AAH00600 BAB71095 CAG33459 EAW81785 EAW81786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca