InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHP2

Summary

InnateDB Protein

IDBP-20871.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHP2

Protein Name

Calcineurin B homologous protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300113

InnateDB Gene

IDBG-20869 (CHP2)

Protein Structure

UniProt Annotation

Function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. {ECO:0000269PubMed:12226101, ECO:0000269PubMed:18815128}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21392185}. Cytoplasm {ECO:0000269PubMed:21392185}. Cell membrane {ECO:0000269PubMed:21392185}. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in malignantly transformed cells but not detected in normal tissues. {ECO:0000269PubMed:12097419, ECO:0000269PubMed:12226101}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0010922	positive regulation of phosphatase activity
GO:0015031	protein transport
GO:0042307	positive regulation of protein import into nucleus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070886	positive regulation of calcineurin-NFAT signaling cascade
GO:0071277	cellular response to calcium ion