InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppm1e

Summary

InnateDB Protein

IDBP-207280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppm1e

Protein Name

protein phosphatase 1E (PP2C domain containing)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061278

InnateDB Gene

IDBG-207278 (Ppm1e)

Protein Structure

UniProt Annotation

Function

Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity). Dephosphorylates PRKAA2. {ECO:0000250, ECO:0000269PubMed:23088624}.

Subcellular Localization

Nucleus. Cytoplasm. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0035690	cellular response to drug
GO:0035970	peptidyl-threonine dephosphorylation
GO:0051496	positive regulation of stress fiber assembly