InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ints1

Summary

InnateDB Protein

IDBP-206724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ints1

Protein Name

integrator complex subunit 1

Synonyms

1110015K06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072406

InnateDB Gene

IDBG-206722 (Ints1)

Protein Structure

UniProt Annotation

Function

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005488	binding

Biological Process

GO:0001832	blastocyst growth
GO:0001833	inner cell mass cell proliferation
GO:0016180	snRNA processing
GO:0034474	U2 snRNA 3'-end processing
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process