Version 5.4
Mus musculus Protein: Agtrap
Summary
InnateDB Protein IDBP-204184.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agtrap
Protein Name angiotensin II, type I receptor-associated protein
Synonyms 3300002E14Rik; AT1R; Atrap; D4Wsu124e;
Species Mus musculus
Ensembl Protein ENSMUSP00000030865
InnateDB Gene IDBG-204182 (Agtrap)
Protein Structure
UniProt Annotation
Function Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. {ECO:0000269PubMed:10358057, ECO:0000269PubMed:15757644}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous but more abundant in kidney, testis and heart. {ECO:0000269PubMed:10358057}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004945 angiotensin type II receptor activity
GO:0005515 protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0008217 regulation of blood pressure
GO:0038166 angiotensin-activated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID MGI:1339977
InterPro IPR009436 Angiotensin II, type I receptor-associated
PFAM PF06396
PRINTS
PIRSF
SMART SM00805
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WVK0
PhosphoSite PhosphoSite-Q9WVK0
TrEMBL
UniProt Splice Variant
Entrez Gene 11610
UniGene Mm.46247
RefSeq NP_033772
MGI ID
MGI Symbol Agtrap
OMIM
CCDS CCDS18930
HPRD
IMGT
EMBL AF102548 AK007383 AK007502 AK036598 AK152467 AL606929 BC046820 BC057196 CH466594 CU207376
GenPept AAD25997 AAH46820 AAH57196 BAB25001 BAB25074 BAC29501 BAE31243 CAM14899 CAQ51920 EDL14800

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca