InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clpb

Summary

InnateDB Protein

IDBP-202139.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clpb

Protein Name

ClpB caseinolytic peptidase B homolog (E. coli)

Synonyms

AL118244; Skd3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001884

InnateDB Gene

IDBG-202137 (Clpb)

Protein Structure

UniProt Annotation

Function

May function as a regulatory ATPase and be related to secretion/protein trafficking process.

Subcellular Localization

Disease Associations

Tissue Specificity

Present in a wide variety of tissues, is abundant in mouse heart, skeletal muscle and kidney, and is most abundant in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016301	kinase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0008152	metabolic process
GO:0034605	cellular response to heat

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1100517

InterPro

IPR001270 ClpA/B family
IPR002078 RNA polymerase sigma factor 54 interaction domain
IPR002110 Ankyrin repeat
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR010488 Zeta toxin domain
IPR011704 ATPase, dynein-related, AAA domain
IPR019489 Clp ATPase, C-terminal
IPR020683 Ankyrin repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM