InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fshr

Summary

InnateDB Protein

IDBP-201760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fshr

Protein Name

follicle stimulating hormone receptor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040477

InnateDB Gene

IDBG-201758 (Fshr)

Protein Structure

UniProt Annotation

Function

Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004963	follicle-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001545	primary ovarian follicle growth
GO:0001932	regulation of protein phosphorylation
GO:0003073	regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0007626	locomotory behavior
GO:0009992	cellular water homeostasis
GO:0010640	regulation of platelet-derived growth factor receptor signaling pathway
GO:0022602	ovulation cycle process
GO:0031175	neuron projection development
GO:0032350	regulation of hormone metabolic process
GO:0033044	regulation of chromosome organization
GO:0033146	regulation of intracellular estrogen receptor signaling pathway
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0035092	sperm chromatin condensation
GO:0035093	spermatogenesis, exchange of chromosomal proteins
GO:0042699	follicle-stimulating hormone signaling pathway
GO:0043408	regulation of MAPK cascade
GO:0045056	transcytosis
GO:0045670	regulation of osteoclast differentiation
GO:0045779	negative regulation of bone resorption
GO:0060009	Sertoli cell development
GO:0060011	Sertoli cell proliferation
GO:0060065	uterus development
GO:0060408	regulation of acetylcholine metabolic process
GO:0071711	basement membrane organization

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:95583

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR002131 Glycoprotein hormone receptor family
IPR002272 Follicle stimulating hormone receptor
IPR002274 Thyrotropin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR024635 Gonadotropin hormone receptor, transmembrane domain

PFAM

PF00001
PF01462
PF00560
PF13504
PF13855
PF12369

PRINTS

PR00237
PR00373
PR01143
PR01145

PIRSF

SMART

SM00013

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt