Version 5.4
Mus musculus Protein: Depdc1a
Summary
InnateDB Protein IDBP-201389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Depdc1a
Protein Name DEP domain containing 1a
Synonyms 5830484J08Rik; Depdc1;
Species Mus musculus
Ensembl Protein ENSMUSP00000029825
InnateDB Gene IDBG-201387 (Depdc1a)
Protein Structure
UniProt Annotation
Function May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Colocalizes with ZNF224 at the nucleus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID MGI:1923381
InterPro IPR000591 DEP domain
IPR008936 Rho GTPase activation protein
PFAM PF00610
PRINTS
PIRSF
SMART SM00049
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CIG0
PhosphoSite PhosphoSite-Q8CIG0
TrEMBL
UniProt Splice Variant
Entrez Gene 76131
UniGene Mm.473495
RefSeq NP_083799
MGI ID
MGI Symbol Depdc1a
OMIM
CCDS CCDS17936
HPRD
IMGT
EMBL AK050456 AK088719 BC005799 BC023934
GenPept AAH05799 AAH23934 BAC34267 BAC40526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca