InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mc1r

Summary

InnateDB Protein

IDBP-199168.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mc1r

Protein Name

melanocortin 1 receptor

Synonyms

e; Mshra; Tob;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095929

InnateDB Gene

IDBG-199166 (Mc1r)

Protein Structure

UniProt Annotation

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Melanocytes and corticoadrenal tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042562	hormone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0010739	positive regulation of protein kinase A signaling
GO:0019233	sensory perception of pain
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032720	negative regulation of tumor necrosis factor production
GO:0035556	intracellular signal transduction
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051897	positive regulation of protein kinase B signaling
GO:0060259	regulation of feeding behavior
GO:0070914	UV-damage excision repair
GO:0090037	positive regulation of protein kinase C signaling
GO:2000253	positive regulation of feeding behavior

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:99456

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000761 Melanocyte-stimulating hormone receptor
IPR001671 Melanocortin/ACTH receptor
IPR001908 Melanocortin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00536
PR00534
PR00535

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q01727