InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pik3r5

Summary

InnateDB Protein

IDBP-188690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3r5

Protein Name

phosphoinositide-3-kinase, regulatory subunit 5, p101

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021283

InnateDB Gene

IDBG-188688 (Pik3r5)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0005944	1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
GO:0016020	membrane