InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ap1s2

Summary

InnateDB Protein

IDBP-184257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap1s2

Protein Name

adaptor-related protein complex 1, sigma 2 subunit

Synonyms

1500012A13Rik; AI853648; EST1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066185

InnateDB Gene

IDBG-184253 (Ap1s2)

Protein Structure

UniProt Annotation

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008565	protein transporter activity

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005905	coated pit
GO:0030117	membrane coat
GO:0030659	cytoplasmic vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1889383

InterPro

IPR011012 Longin-like domain
IPR016635 Adaptor protein complex, sigma subunit
IPR022775 AP complex, mu/sigma subunit

PFAM

PF01217

PRINTS

PIRSF

PIRSF015588

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DB50

PhosphoSite

PhosphoSite-Q9DB50

TrEMBL

UniProt Splice Variant

Entrez Gene

108012

UniGene

Mm.490499

RefSeq

NP_001277308

MGI ID

MGI Symbol

Ap1s2

OMIM

CCDS

CCDS72465

HPRD

IMGT

EMBL

AK005223 AK045558 AK047724 BX469932

GenPept

BAB23892 BAC32418 BAC33140 CAM46173