InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AQP4

Summary

InnateDB Protein

IDBP-1842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AQP4

Protein Name

aquaporin 4

Synonyms

HMIWC2; MIWC;

Species

Homo sapiens

Ensembl Protein

ENSP00000372654

InnateDB Gene

IDBG-1836 (AQP4)

Protein Structure

UniProt Annotation

Function

Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Brain - muscle >> heart, kidney, lung, and trachea.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005372	water transmembrane transporter activity
GO:0015250	water channel activity
GO:0015288	porin activity

Biological Process

GO:0006810	transport
GO:0006833	water transport
GO:0007399	nervous system development
GO:0007565	female pregnancy
GO:0007588	excretion
GO:0007605	sensory perception of sound
GO:0009314	response to radiation
GO:0015670	carbon dioxide transport
GO:0030104	water homeostasis
GO:0042538	hyperosmotic salinity response
GO:0050891	multicellular organismal water homeostasis
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0055085	transmembrane transport
GO:0070295	renal water absorption
GO:0071346	cellular response to interferon-gamma
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0043234	protein complex