InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Setmar

Summary

InnateDB Protein

IDBP-174234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Setmar

Protein Name

SET domain and mariner transposase fusion gene

Synonyms

5830404F24Rik; Etet2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048225

InnateDB Gene

IDBG-174232 (Setmar)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36' (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042803	protein homodimerization activity
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000729	DNA double-strand break processing
GO:0000737	DNA catabolic process, endonucleolytic
GO:0034968	histone lysine methylation
GO:0071157	negative regulation of cell cycle arrest
GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining
GO:2001251	negative regulation of chromosome organization