InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctdsp1

Summary

InnateDB Protein

IDBP-166989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctdsp1

Protein Name

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027367

InnateDB Gene

IDBG-166987 (Ctdsp1)

Protein Structure

UniProt Annotation

Function

Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000250, ECO:0000269PubMed:15681389}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression is restricted to non-neuronal tissues. {ECO:0000269PubMed:15681389}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008420	CTD phosphatase activity
GO:0016791	phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006470	protein dephosphorylation
GO:0045665	negative regulation of neuron differentiation
GO:0050768	negative regulation of neurogenesis