InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnip1

Summary

InnateDB Protein

IDBP-161310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnip1

Protein Name

Kv channel-interacting protein 1

Synonyms

KCHIP1; Kchip1.2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069063

InnateDB Gene

IDBG-161306 (Kcnip1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14572458}; Peripheral membrane protein {ECO:0000269PubMed:14572458}.

Disease Associations

Tissue Specificity

Expressed in brain. Found in a subpopulation of neurons widely distributed and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei. {ECO:0000269PubMed:15363885}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005267	potassium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity
GO:0044325	ion channel binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0007165	signal transduction
GO:0034765	regulation of ion transmembrane transport
GO:0045760	positive regulation of action potential
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005886	plasma membrane
GO:0030425	dendrite
GO:0034705	potassium channel complex
GO:0043025	neuronal cell body