InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6ap1

Summary

InnateDB Protein

IDBP-155787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6ap1

Protein Name

ATPase, H+ transporting, lysosomal accessory protein 1

Synonyms

16A; AC45; AI316502; Atp6ip1; Atp6s1; AW108110; C7-1; CF2; mFLJ00383; VATPS1; XAP-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019231

InnateDB Gene

IDBG-155785 (Atp6ap1)

Protein Structure

UniProt Annotation

Function

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000250}.

Subcellular Localization

Vacuole membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0017137	Rab GTPase binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0015991	ATP hydrolysis coupled proton transport
GO:0045669	positive regulation of osteoblast differentiation
GO:0045780	positive regulation of bone resorption
GO:0045851	pH reduction
GO:0045921	positive regulation of exocytosis
GO:0051656	establishment of organelle localization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2001206	positive regulation of osteoclast development

Cellular Component

GO:0005774	vacuolar membrane
GO:0016021	integral component of membrane
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0070062	extracellular vesicular exosome