InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Herc6

Summary

InnateDB Protein

IDBP-151113.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Herc6

Protein Name

hect domain and RLD 6

Synonyms

1700121D12Rik; 2510038N07Rik; 4930427L17Rik; AI451296; CEB1; Herc5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031817

InnateDB Gene

IDBG-151109 (Herc6)

Protein Structure

UniProt Annotation

Function

Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. {ECO:0000269PubMed:22272257}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:22272257}. Note=Exclusively cytoplasmic.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0016874	ligase activity

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1914388

InterPro

IPR000408 Regulator of chromosome condensation, RCC1
IPR000569 HECT
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

PFAM

PF00415
PF00632

PRINTS

PR00633

PIRSF

SMART

SM00119

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt