InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpk1

Summary

InnateDB Protein

IDBP-143265.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpk1

Protein Name

thiamine pyrophosphokinase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065631

InnateDB Gene

IDBG-143263 (Tpk1)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. {ECO:0000269PubMed:10567383, ECO:0000269PubMed:16365036}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in kidney and liver, and at lower levels in heart, brain and testis. {ECO:0000269PubMed:10567383}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004788	thiamine diphosphokinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006772	thiamine metabolic process
GO:0009229	thiamine diphosphate biosynthetic process
GO:0016310	phosphorylation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1352500

InterPro

IPR006282 Thiamin pyrophosphokinase
IPR007371 Thiamin pyrophosphokinase, catalytic domain
IPR007373 Thiamin pyrophosphokinase, vitamin B1-binding domain
IPR016966 Thiamin pyrophosphokinase, eukaryotic

PFAM

PF04263
PF04265

PRINTS

PIRSF

PIRSF031057

SMART

SM00983

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt