InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ikbkb

Summary

InnateDB Protein

IDBP-141023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ikbkb

Protein Name

inhibitor of kappaB kinase beta

Synonyms

AI132552; IKK-2; IKK-beta; IKK[b]; IKK2; IKKbeta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033939

InnateDB Gene

IDBG-141021 (Ikbkb)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 169 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	72 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	169 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008384	IkappaB kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0097110	scaffold protein binding

Biological Process

GO:0001782	B cell homeostasis
GO:0006468	protein phosphorylation
GO:0007252	I-kappaB phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010765	positive regulation of sodium ion transport
GO:0023014	signal transduction by phosphorylation
GO:0042501	serine phosphorylation of STAT protein
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0071356	cellular response to tumor necrosis factor
GO:2001259	positive regulation of cation channel activity

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1338071

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR010978 tRNA-binding arm
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022007 I-kappa-kinase-beta NEMO binding domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF06293
PF12179

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt