Version 5.4
Homo sapiens Protein: CDC42SE1
Summary
InnateDB Protein IDBP-102281.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42SE1
Protein Name CDC42 small effector 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349773
InnateDB Gene IDBG-102279 (CDC42SE1)
Protein Structure
UniProt Annotation
Function Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269PubMed:10816584, ECO:0000269PubMed:15840583, ECO:0000269PubMed:17045588}.
Subcellular Localization Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Recruited to the activated TCR prior actin polymerization.
Disease Associations
Tissue Specificity Widely expressed. Expressed at higher level in T-lymphocytes, dendritic and whole blood cells. {ECO:0000269PubMed:15840583}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
Biological Process
GO:0006909 phagocytosis
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000095 CRIB domain
PFAM PF00786
PRINTS
PIRSF
SMART SM00285
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRR8
PhosphoSite PhosphoSite-Q9NRR8
TrEMBL
UniProt Splice Variant
Entrez Gene 56882
UniGene Hs.22065
RefSeq NP_064624
HUGO HGNC:17719
OMIM
CCDS CCDS981
HPRD 16694
IMGT
EMBL AF187845 AF286041 AF286592 AL590133 BC012796 BC041604 CH471121
GenPept AAF87597 AAF97248 AAG17723 AAH12796 AAH41604 CAI13349 EAW53477 EAW53478 EAW53479

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca