Version 5.4
Interaction: MAP4K4 :: BIRC2 XML
Summary
InnateDB Group ID 228445
Short name MAP4K4 :: BIRC2
Full name MAP4K4 interacts with BIRC2
Interaction type physical association
Participants
Participant 1
Molecule: IDBG-63853
Molecule type: protein
Species: Homo sapiens
HUGO: MAP4K4
Full name: mitogen-activated protein kinase kinase kinase kinase 4
Direction: input
Biological role: unspecified role
Participant 2
Molecule: IDBG-69075
Molecule type: protein
Species: Homo sapiens
HUGO: BIRC2
Full name: baculoviral IAP repeat containing 2
Direction: input
Biological role: unspecified role
Evidence Reference 1
InnateDB ID IDB-187309.1
Last Modified 2010-03-12
Review status reviewed [Report errors or provide feedback]
Source database INNATEDB
Source database ID IDB-187309
PMID 20184394
Interaction detection method anti tag coimmunoprecipitation
Host system invitro
Host organism Homo sapiens
Cell status cell line
Cell line 293
Cell type epithelial cell
Tissue type embryonic kidney cell line
Comment Ub-K48 was added to mark target proteins for proteosome-mediated proteolytic destruction. K48-polyubiquitylation on MAP4K4 was reduced when Myc-TRAF2 was expressed, suggesting thta TRAF2 could suppress ubiquitin ligase activity of BIRC2. Tags: Flag-MAP4K4, Myc-BIRC2
Participants
Participant Identification Method Experimental Role Participant Accession
1) MAP4K4 anti tag western blot bait
2) BIRC2 anti tag western blot prey
Evidence Reference 2
InnateDB ID IDB-187377.1
Last Modified 2010-03-12
Review status reviewed [Report errors or provide feedback]
Source database INNATEDB
Source database ID IDB-187377
PMID 20184394
Interaction detection method anti tag coimmunoprecipitation
Host system invitro
Host organism Homo sapiens
Cell status cell line
Cell line 293
Cell type epithelial cell
Tissue type embryonic kidney cell line
Comment Ub-K48 was added to mark target proteins for proteosome-mediated proteolytic destruction. K48-polyubiquitylation on MAP4K4 was reduced when Myc-TRAF2 was expressed, suggesting thta TRAF2 could suppress ubiquitin ligase activity of BIRC2. Tags: Flag-MAP4K4, Myc-BIRC2
Participants
Participant Identification Method Experimental Role Participant Accession
1) MAP4K4 anti tag western blot bait
2) BIRC2 anti tag western blot prey

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca