InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEC61B

Summary

InnateDB Gene

IDBG-78553.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC61B

Gene Name

Sec61 beta subunit

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000106803

Encoded Proteins

IDBP-78555

Sec61 beta subunit

IDBP-809848

Sec61 beta subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:99222064-99230615

Strand

Forward strand

Band

q22.33

Transcripts

ENST00000223641	ENSP00000223641
ENST00000498603	ENSP00000474122
ENST00000481573

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0048408	epidermal growth factor binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006412	translation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030970	retrograde protein transport, ER to cytosol
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031205	endoplasmic reticulum Sec complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000092116

View Gene Order

ENSBTAG00000002457

Not yet available

Pathways

NETPATH

REACTOME

REACT_111178

ER-Phagosome pathway pathway

REACT_115902

SRP-dependent cotranslational protein targeting to membrane pathway

REACT_1014

Translation pathway

REACT_111119

Antigen processing-Cross presentation pathway

REACT_17015

Metabolism of proteins pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

REACT_71

Gene Expression pathway

KEGG

hsa05110

Vibrio cholerae infection pathway

hsa03060

Protein export pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_006808

HUGO

OMIM

CCDS

CCDS6741

HPRD

06715

IMGT

EMBL

GenPept

RNA Seq Atlas