Version 5.4
Homo sapiens Gene: CEP250
Summary
InnateDB Gene IDBG-70106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP250
Gene Name centrosomal protein 250kDa
Synonyms C-NAP1; CEP2; CNAP1
Species Homo sapiens
Ensembl Gene ENSG00000126001
Encoded Proteins
IDBP-235146
centrosomal protein 250kDa
IDBP-235148
centrosomal protein 250kDa
IDBP-372968
centrosomal protein 250kDa
IDBP-372969
centrosomal protein 250kDa
IDBP-373029
centrosomal protein 250kDa
IDBP-373031
centrosomal protein 250kDa
IDBP-373034
centrosomal protein 250kDa
IDBP-373036
centrosomal protein 250kDa
IDBP-476420
centrosomal protein 250kDa
IDBP-813072
centrosomal protein 250kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:35455164-35519280
Strand Forward strand
Band q11.22
Transcripts
ENST00000397527 ENSP00000380661
ENST00000397524 ENSP00000380658
ENST00000446710 ENSP00000398747
ENST00000420564 ENSP00000414651
ENST00000425934 ENSP00000413827
ENST00000425096 ENSP00000400200
ENST00000425525 ENSP00000394346
ENST00000422671 ENSP00000395992
ENST00000476146
ENST00000461386 ENSP00000419137
ENST00000465987
ENST00000474829
ENST00000487467
ENST00000621352 ENSP00000482323
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 228 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 228 [view]
Protein-Protein 228 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0008104 protein localization
GO:0010457 centriole-centriole cohesion
GO:0030997 regulation of centriole-centriole cohesion
GO:0033365 protein localization to organelle
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005929 cilium
GO:0031616 spindle pole centrosome
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038241
View Gene Order
ENSBTAG00000006021
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443976
RefSeq NM_007186 XM_005260262 XM_005260263 XM_005260265 XM_006723690 XM_006723691 XM_006723692 XM_006723693
HUGO
OMIM
CCDS CCDS13255
HPRD 09877
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca