InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BMF

Summary

InnateDB Gene

IDBG-646206.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMF

Gene Name

bcl-2-modifying factor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012180

Encoded Proteins

IDBP-698988

bcl-2-modifying factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104081:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:35856697-35871287

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016157

ENSBTAP00000016157

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0032464	positive regulation of protein homooligomerization
GO:0043276	anoikis
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:2001234	negative regulation of apoptotic signaling pathway
GO:2001235	positive regulation of apoptotic signaling pathway