Version 5.4
Homo sapiens Gene: PPM1E
Summary
InnateDB Gene IDBG-61523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPM1E
Gene Name protein phosphatase, Mg2+/Mn2+ dependent, 1E
Synonyms caMKN; CaMKP-N; POPX1; PP2CH
Species Homo sapiens
Ensembl Gene ENSG00000175175
Encoded Proteins
IDBP-61525
protein phosphatase, Mg2+/Mn2+ dependent, 1E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5\'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:58755869-58985176
Strand Forward strand
Band q22
Transcripts
ENST00000308249 ENSP00000312411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0035690 cellular response to drug
GO:0035970 peptidyl-threonine dephosphorylation
GO:0051496 positive regulation of stress fiber assembly
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046442
View Gene Order
ENSBTAG00000010788
Not yet available
Cross-References
SwissProt Q8WY54
TrEMBL A7E2X1
UniProt Splice Variant
Entrez Gene 22843
UniGene Hs.245044
RefSeq NM_014906 XM_005257169
HUGO HGNC:19322
OMIM
CCDS CCDS11613
HPRD
IMGT
EMBL AB028995 AC025521 AC100832 AF260269 AF520614 AK289966 BC136290 BC151228 CH471109 CR749253 DA497512 DA791319
GenPept AAF70325 AAI36291 AAI51229 AAM76058 BAA83024 BAF82655 CAH18109 EAW94429
RNA Seq Atlas 22843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca