Version 5.4
Homo sapiens Gene: RSU1
Summary
InnateDB Gene IDBG-57666.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RSU1
Gene Name Ras suppressor protein 1
Synonyms RSP-1
Species Homo sapiens
Ensembl Gene ENSG00000148484
Encoded Proteins
IDBP-57668
Ras suppressor protein 1
IDBP-57670
Ras suppressor protein 1
IDBP-813022
Ras suppressor protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:16590611-16817528
Strand Reverse strand
Band p13
Transcripts
ENST00000345264 ENSP00000339521
ENST00000377921 ENSP00000367154
ENST00000377911
ENST00000464074
ENST00000602389 ENSP00000473588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0034329 cell junction assembly
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026727
View Gene Order
ENSBTAG00000027446
Not yet available
Pathways
NETPATH
REACTOME
REACT_20580
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q15404
TrEMBL
UniProt Splice Variant
Entrez Gene 6251
UniGene
RefSeq NM_152724 NM_012425
HUGO HGNC:10464
OMIM 179555
CCDS CCDS31157 CCDS7112
HPRD
IMGT
EMBL AC073367 AK292911 AK312520 AL365215 BC005993 BC008691 BC015644 CH471072 CR536521 CR541840 EF445013 L12535
GenPept AAA60292 AAH05993 AAH08691 AAH15644 ACA06048 ACA06049 ACA06050 BAF85600 BAG35419 CAG38758 CAG46639 CAH73632 CAH73633 EAW86222 EAW86223 EAW86224
RNA Seq Atlas 6251

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca