Version 5.4
Homo sapiens Gene: KCNIP1
Summary
InnateDB Gene IDBG-57271.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNIP1
Gene Name Kv channel interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182132
Encoded Proteins
IDBP-57273
Kv channel interacting protein 1
IDBP-57277
Kv channel interacting protein 1
IDBP-57279
Kv channel interacting protein 1
IDBP-381444
Kv channel interacting protein 1
IDBP-381446
Kv channel interacting protein 1
IDBP-476487
Kv channel interacting protein 1
IDBP-483535
Kv channel interacting protein 1
IDBP-812842
Kv channel interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:170353487-170736632
Strand Forward strand
Band q35.1
Transcripts
ENST00000377360 ENSP00000366577
ENST00000328939 ENSP00000329686
ENST00000390656 ENSP00000375071
ENST00000434108 ENSP00000414886
ENST00000411494 ENSP00000395323
ENST00000518527
ENST00000517344 ENSP00000431053
ENST00000520740 ENSP00000431102
ENST00000616807 ENSP00000478151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0044325 ion channel binding
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0005513 detection of calcium ion
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0045760 positive regulation of action potential
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0034705 potassium channel complex
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053519
View Gene Order
ENSBTAG00000002865
Not yet available
Cross-References
SwissProt
TrEMBL E5RJY5
UniProt Splice Variant
Entrez Gene 30820
UniGene Hs.639278
RefSeq NM_001034837 NM_001034838 NM_001278339 NM_001278340 NM_014592
HUGO HGNC:15521
OMIM 604660
CCDS CCDS34285 CCDS34286 CCDS4374 CCDS64312 CCDS64313
HPRD 06879
IMGT
EMBL AC008619 AC008719 AC027306 AC027312 AC034199 AC113432 AC134820
GenPept
RNA Seq Atlas 30820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca