Version 5.4
Homo sapiens Gene: GALNT6
Summary
InnateDB Gene IDBG-33414.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GALNT6
Gene Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
Synonyms GALNAC-T6; GalNAcT6
Species Homo sapiens
Ensembl Gene ENSG00000139629
Encoded Proteins
IDBP-33416
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
IDBP-597009
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
IDBP-812102
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812104
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812106
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812109
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812113
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812115
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812116
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812117
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812118
polypeptide N-acetylgalactosaminyltransferase 6
IDBP-812120
polypeptide N-acetylgalactosaminyltransferase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:51351247-51392867
Strand Reverse strand
Band q13.13
Transcripts
ENST00000356317 ENSP00000348668
ENST00000543196 ENSP00000444171
ENST00000603680
ENST00000603641 ENSP00000474670
ENST00000604381 ENSP00000474101
ENST00000604847 ENSP00000474515
ENST00000604426 ENSP00000473918
ENST00000605617 ENSP00000473836
ENST00000603188 ENSP00000474052
ENST00000603563 ENSP00000473948
ENST00000605138 ENSP00000473981
ENST00000604506 ENSP00000474163
ENST00000605055 ENSP00000474483
ENST00000603203
ENST00000605822
ENST00000605089
ENST00000603482
ENST00000605367
ENST00000605720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0046872 metal ion binding
Biological Process
GO:0006493 protein O-linked glycosylation
GO:0008152 metabolic process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037280
View Gene Order
ENSBTAG00000017943
Not yet available
Pathways
NETPATH
REACTOME
REACT_115606
O-linked glycosylation of mucins pathway
REACT_22161
Post-translational protein modification pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00512
Mucin type O-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL S4R310 S4R345 S4R355 S4R370 S4R396 S4R3L4
UniProt Splice Variant
Entrez Gene 11226
UniGene
RefSeq NM_007210 XM_005268607 XM_005268608 XM_006719214
HUGO HGNC:4128
OMIM 605148
CCDS CCDS8813
HPRD
IMGT
EMBL AC046135
GenPept
RNA Seq Atlas 11226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca