Version 5.4
Homo sapiens Gene: WDR61
Summary
InnateDB Gene IDBG-24605.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR61
Gene Name WD repeat domain 61
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140395
Encoded Proteins
IDBP-24607
WD repeat domain 61
IDBP-600244
WD repeat domain 61
IDBP-747451
IDBP-586431
WD repeat domain 61
IDBP-593079
WD repeat domain 61
IDBP-596178
WD repeat domain 61
IDBP-601721
WD repeat domain 61
IDBP-598221
WD repeat domain 61
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78277835-78299794
Strand Reverse strand
Band q25.1
Transcripts
ENST00000267973 ENSP00000267973
ENST00000558453 ENSP00000453118
ENST00000560807 ENSP00000455689
ENST00000558192
ENST00000558412
ENST00000559332
ENST00000559940
ENST00000558311 ENSP00000453801
ENST00000558459 ENSP00000453024
ENST00000560569 ENSP00000453902
ENST00000560610 ENSP00000453493
ENST00000559848 ENSP00000453589
ENST00000560063
ENST00000559700
ENST00000558840
ENST00000560946
ENST00000561347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016055 Wnt signaling pathway
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation
GO:2001162 positive regulation of histone H3-K79 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016593 Cdc73/Paf1 complex
GO:0035327 transcriptionally active chromatin
GO:0055087 Ski complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061559
View Gene Order
ENSBTAG00000015944
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YM76 H0YMF9
UniProt Splice Variant
Entrez Gene 80349
UniGene Hs.513055
RefSeq NM_025234 XM_005254698
HUGO HGNC:30300
OMIM 609540
CCDS CCDS10300
HPRD 15236
IMGT
EMBL AC090607
GenPept
RNA Seq Atlas 80349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca