Version 5.4
Homo sapiens Gene: PPAT
Summary
InnateDB Gene IDBG-20011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAT
Gene Name phosphoribosyl pyrophosphate amidotransferase
Synonyms ATASE; GPAT; PRAT
Species Homo sapiens
Ensembl Gene ENSG00000128059
Encoded Proteins
IDBP-20013
phosphoribosyl pyrophosphate amidotransferase
IDBP-476151
phosphoribosyl pyrophosphate amidotransferase
IDBP-477100
phosphoribosyl pyrophosphate amidotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:56393362-56435615
Strand Reverse strand
Band q12
Transcripts
ENST00000264220 ENSP00000264220
ENST00000425339
ENST00000507648
ENST00000510643 ENSP00000423781
ENST00000507724 ENSP00000425119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004044 amidophosphoribosyltransferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001822 kidney development
GO:0006144 purine nucleobase metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006543 glutamine catabolic process
GO:0007595 lactation
GO:0008152 metabolic process
GO:0009113 purine nucleobase biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0019693 ribose phosphate metabolic process
GO:0031100 organ regeneration
GO:0032869 cellular response to insulin stimulus
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0051289 protein homotetramerization
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0060135 maternal process involved in female pregnancy
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029246
View Gene Order
ENSBTAG00000010571
Not yet available
Pathways
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL D6RCC8
UniProt Splice Variant
Entrez Gene 5471
UniGene Hs.331420 Hs.603588 Hs.664052 Hs.717743
RefSeq NM_002703
HUGO HGNC:9238
OMIM 172450
CCDS CCDS3505
HPRD 01402
IMGT
EMBL AC068620
GenPept
RNA Seq Atlas 5471

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca