InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lphn2

Summary

InnateDB Gene

IDBG-199673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lphn2

Gene Name

latrophilin 2

Synonyms

AI450192; Gm619; Lec1; Lphh1; mKIAA0786

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028184

Encoded Proteins

IDBP-199709

latrophilin 2

IDBP-269405

latrophilin 2

IDBP-621700

latrophilin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117114:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:148815586-148989316

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098518	ENSMUSP00000096118
ENSMUST00000106128	ENSMUSP00000101734
ENSMUST00000168352	ENSMUSP00000132116

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0008150	biological_process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117114

View Gene Order

ENSBTAG00000012305

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.462301 Mm.472194 Mm.9776

RefSeq

NM_001081298 XM_006502423 XM_006502424 XM_006502441 XM_006502443 XM_006502444 XM_006502446 XM_006502448 XM_006502449 XM_006502451 XM_006502452 XM_006502453 XM_006502454 XM_006502455 XM_006502457 XM_006502459

OMIM

CCDS

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas