Version 5.4
Mus musculus Gene: Depdc5
Summary
InnateDB Gene IDBG-151911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Depdc5
Gene Name DEP domain containing 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037426
Encoded Proteins
IDBP-151913
DEP domain containing 5
IDBP-151917
DEP domain containing 5
IDBP-401187
DEP domain containing 5
IDBP-401186
DEP domain containing 5
IDBP-401181
DEP domain containing 5
IDBP-532296
DEP domain containing 5
IDBP-537720
DEP domain containing 5
IDBP-535196
DEP domain containing 5
IDBP-532500
DEP domain containing 5
IDBP-534034
DEP domain containing 5
IDBP-540684
DEP domain containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100150:
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:32863701-32994231
Strand Forward strand
Band B1
Transcripts
ENSMUST00000087897 ENSMUSP00000085207
ENSMUST00000049780 ENSMUSP00000052807
ENSMUST00000119705 ENSMUSP00000113862
ENSMUST00000120902 ENSMUSP00000113980
ENSMUST00000118698 ENSMUSP00000112906
ENSMUST00000149350 ENSMUSP00000122461
ENSMUST00000150130 ENSMUSP00000116704
ENSMUST00000139098
ENSMUST00000139463
ENSMUST00000125574 ENSMUSP00000122173
ENSMUST00000124780 ENSMUSP00000120120
ENSMUST00000137169 ENSMUSP00000121089
ENSMUST00000141812
ENSMUST00000130461 ENSMUSP00000118681
ENSMUST00000127560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005096 GTPase activator activity
Biological Process
GO:0008150 biological_process
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100150
View Gene Order
ENSBTAG00000001295
Not yet available
Cross-References
SwissProt
TrEMBL D3Z419 D3Z5Y4 D3Z7M7
UniProt Splice Variant
Entrez Gene 277854
UniGene Mm.101524
RefSeq NM_001025426 NM_001170567 NM_177786 XM_006503984 XM_006503987
OMIM
CCDS CCDS19196 CCDS19197 CCDS51463
HPRD
IMGT
MGI ID MGI:2141101
MGI Symbol Depdc5
EMBL AC108773 AC122203
GenPept
RNA Seq Atlas 277854

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca