Version 5.4
Mus musculus Gene: Aqp4
Summary
InnateDB Gene IDBG-129483.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aqp4
Gene Name aquaporin 4
Synonyms WCH4
Species Mus musculus
Ensembl Gene ENSMUSG00000024411
Encoded Proteins
IDBP-129485
aquaporin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171885:
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:15389394-15403684
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000079081 ENSMUSP00000078088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015250 water channel activity
GO:0015288 porin activity
Biological Process
GO:0006810 transport
GO:0006833 water transport
GO:0007565 female pregnancy
GO:0007605 sensory perception of sound
GO:0009314 response to radiation
GO:0015670 carbon dioxide transport
GO:0030104 water homeostasis
GO:0042538 hyperosmotic salinity response
GO:0050891 multicellular organismal water homeostasis
GO:0051260 protein homooligomerization
GO:0051384 response to glucocorticoid
GO:0055085 transmembrane transport
GO:0070295 renal water absorption
GO:0071346 cellular response to interferon-gamma
GO:0071392 cellular response to estradiol stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030315 T-tubule
GO:0042383 sarcolemma
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171885
View Gene Order
ENSBTAG00000019037
Not yet available
Pathways
NETPATH
REACTOME
REACT_226335
Aquaporin-mediated transport pathway
REACT_213947
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_259079
Passive transport by Aquaporins pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
mmu04962
Vasopressin-regulated water reabsorption pathway
mmu04976
Bile secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23826
Passive transport by Aquaporins pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_216552
Aquaporin-mediated transport pathway
REACT_202137
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_208085
Passive transport by Aquaporins pathway
KEGG
hsa04962
Vasopressin-regulated water reabsorption pathway
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt P55088
TrEMBL Q50H70 Q8BR89 Q8K4M1
UniProt Splice Variant
Entrez Gene 11829
UniGene Mm.250786
RefSeq NM_009700 XM_006525540
OMIM
CCDS CCDS29073
HPRD
IMGT
MGI ID MGI:107387
MGI Symbol Aqp4
EMBL AF219992 AF469168 AF469169 AK045357 AY484964 AY484965 AY484966 AY728043 AY728044 AY728045 AY803942 AY803943 AY803944 BC024526 CT010362 U33012 U48397 U48398 U48399 U48400 U88623
GenPept AAA84923 AAB41568 AAB41569 AAB41570 AAB41571 AAC53155 AAG44243 AAH24526 AAL73545 AAL73546 AAM81576 AAS21131 AAS21132 AAS21133 AAX07194 AAX07195 AAX07196 AAX31139 AAX31140 AAX31141 BAC32325 CAJ18569
RNA Seq Atlas 11829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca